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Panel's Recommendations Regarding Co-receptor Tropism Assays
Panel's Recommendations
  • A co-receptor tropism assay should be performed whenever the use of a CCR5 co-receptor antagonist is being considered (AI).
  • Co-receptor tropism testing is also recommended for patients who exhibit virologic failure on a CCR5 antagonist (BIII).
  • A phenotypic tropism assay is preferred to determine HIV-1 co-receptor usage (AI).
  • A genotypic tropism assay should be considered as an alternative test to predict HIV-1 co-receptor usage (BII).
Rating of Recommendations: A = Strong; B = Moderate; C = Optional
Rating of Evidence: I = Data from randomized controlled trials; II = Data from well-designed nonrandomized trials or observational cohort studies with long-term clinical outcomes; III = Expert opinion
thumbnail Fig. #8201;3

Top panel: the distribution of S20/S3.6 in the general source population, in the sample of HzRG by Seymour et #160;al. (2007), and in our IFRS sample. The IFRS clearly occupy a different regime than the general population, and tend to overlap more with the HzRG. Bottom panel: the histogram of the IFRS S20/S3.6 ratios as in the upper panel, shifted to the right by log(5) #160;= #160;0.7. This takes into account that Norris et #160;al. (2010) found no IR counterparts for IFRS in a stacking analysis with a 5 times higher sensitivity. On average the IFRS then have a S20/S3.6 which is about two times higher than that of the HzRG.

Open with DEXTER
Box Runs Wins 2nds 3rds Win %
1 2 1 0 0 50%
2 1 1 0 0 100%
3 1 0 0 0 0%
4 0 0 0 0 0%
5 0 0 0 0 0%
6 0 0 0 0 0%
7 1 1 0 0 100%
8 0 0 0 0 0%

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